neuroprotective effect of p-coumaric acid in rat model of embolic cerebral ischemia
نویسندگان
چکیده
objective(s): stroke poses a crucial risk for mortality and morbidity. our study aimed to investigate the effect of p-coumaric acid on focal cerebral ischemia in rats. material and methods: rats were randomly divided into four groups, namely group i (control rats), group ii (ischemia rats), group iii (6 hr ischemia + p-coumaric acid rats) and group iv (24 hr ischemia + p-coumaric acid rats). cerebral ischemia was induced via intraluminal monofilament occlusion model. in all groups, the brain was removed after the procedure and rats were sacrificed. malondialdehyde, superoxide dismutase and nuclear respiratory factor-1 were measured in the ischemic hemisphere. the histopathological changes were observed in the right hemisphere within the samples. functional assessment was performed for neurological deficit scores. results: following the treatment, biochemical factors changed significantly. histopathologically, it was shown that p-coumaric acid decreased the oxidative damage. the neurological deficit scores of p-coumaric acid-treated rats were significantly improved after cerebral ischemia. conclusion:our results showed that p-coumaric acid is a neuroprotective agent on account of its strong anti-oxidant and anti-apoptotic features. moreover, p-coumaric acid decreased the focal ischemia. extra effort should be made to introduce p-coumaric acid as a promising therapeutic agent to be utilized for treatment of human cerebral ischemia in the future.
منابع مشابه
Neuroprotective effect of p-coumaric acid in rat model of embolic cerebral ischemia
Objective(s): Stroke poses a crucial risk for mortality and morbidity. Our study aimed to investigate the effect of p-coumaric acid on focal cerebral ischemia in rats. Material and Methods: Rats were randomly divided into four groups, namely Group I (control rats), Group II (ischemia rats), Group III (6 hr ischemia + p-coumaric acid rats) and Group IV (24 hr ischemia + p-coumaric acid rats). C...
متن کاملNeuroprotective effect of p-coumaric acid in rat model of embolic cerebral ischemia
OBJECTIVES Stroke poses a crucial risk for mortality and morbidity. Our study aimed to investigate the effect of p-coumaric acid on focal cerebral ischemia in rats. MATERIAL AND METHODS Rats were randomly divided into four groups, namely Group I (control rats), Group II (ischemia rats), Group III (6 hr ischemia + p-coumaric acid rats) and Group IV (24 hr ischemia + p-coumaric acid rats). Cere...
متن کاملNeuroprotective Consequences of Postconditioning on Embolic Model of Cerebral Ischemia in Rat
متن کامل
neuroprotective consequences of postconditioning on embolic model of cerebral ischemia in rat
0
متن کاملP18: Neuroprotective Effect of Safranal, an Active Ingredient of Crocus Sativus, in a Rat Model of Transient Cerebral Ischemia
Safranal is a monoterpene aldehyde found in saffron (Crocus sativus L.) petals. It has been previously reported that safranal has a wide range of activities such as antioxidant and anti-inflammatory effects. In this study, we examined the effect of safranal on brain injuries in a transient model of focal cerebral ischemia. Transient focal cerebral ischemia was induced by middle cerebral artery ...
متن کاملNeuroprotective Consequences of Postconditioning on Embolic Model of Cerebral Ischemia in Rat
OBJECTIVE(S) It has been reported that ischemic postconditioning, conducted by a series of brief occlusion and release of the bilateral common carotid arteries, confers neuroprotection in permanent or transient models of stroke. However, consequences of postconditioning on embolic stroke have not yet been investigated. MATERIALS AND METHODS In the present study, rats were subjected to embolic...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian journal of basic medical sciencesجلد ۱۸، شماره ۴، صفحات ۳۵۶-۳۶۳
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023